basic FUNCTION
| suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs |
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only COMMD9 and its binding partner, COMMD5, have substantial effects on Notch |
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COMMD9 participates in TFDP1/E2F1 activation and plays a critical role in non-small cell lung cancer |
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COMMD proteins are a conserved family of proteins with central roles in intracellular membrane trafficking and transcription |
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COMMD proteins function as obligatory dimers with conserved domain architectures |