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FLASH GENE
Symbol TMBIM4 contributors: mct - updated : 12-07-2016
HGNC name transmembrane BAX inhibitor motif containing 4
HGNC id 24257
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six membrane-spanning topology with cytosolic N and C termini and a C-terminal reentrant loop
  • possess the di-aspartyl pH sensor responsible for pH sensing identified in TMBIM6 8)
  • a common structure of at least seven transmembrane domains with the last domain being semi-hydrophobic
  • HOMOLOGY
    interspecies homolog to murine Tmbim4
    Homologene
    FAMILY
  • TMBIM family of proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • localized in the endoplasmic reticulum
  • Golgi membrane protein
  • basic FUNCTION
  • represent regulators of cell death pathways (Zhou 2008)
  • play a role in apoptosis
  • is a regulator of intracellular Ca2+ fluxes and apoptosis
  • can oligomerize in a pH-regulated manner, and monomeric TMBIM4 is functional
  • increased cell adhesion, spreading, and migration in a manner that depended on its C-terminal domain
  • Golgi antiapoptotic proteins (GAAP) are highly conserved Golgi membrane proteins that inhibit apoptosis and promote Ca(2+) release from intracellular stores
  • is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain
  • reduce the CaČ&
  • 8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ&
    8314; concentration
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • oligomerization of TMBIM4 is independent of cysteines
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS