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FLASH GENE
Symbol SLC25A25 contributors: - updated : 21-04-2005
HGNC name solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
HGNC id 20663
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two EF-hand calcium binding motifs
  • six transmembrane regions
  • HOMOLOGY
    interspecies homolog to rattus Pcscl
    homolog to murine Slc25a25
    intraspecies homolog to SLC25A24
    homolog to SLC25A23
    Homologene
    FAMILY mitochondrial solute carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • may play an important role in regulating the function of hepatocytes rather than in differentiation
  • responsible for the uptake or efflux of adenine nucleotides into or from mitochondria and hence for the variation in the matrix adenine nucleotide content (which changes in physiopathological situations)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Ca2+ binding
  • ATP-Mg binding
  • phosphate binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS