Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC25A24 contributors: mct - updated : 10-01-2018
HGNC name solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
HGNC id 20662
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal calcium-binding domain (containing four EF-hand motifs)
  • followed by six transmembrane helices
  • a short C terminus
  • HOMOLOGY
    interspecies homolog to murine Slc25a24
    ortholog to rattus MCSC protein
    ortholog to rabbit Efinal
    intraspecies homolog to SLC25A25
    homolog to SLC25A23
    Homologene
    FAMILY mitochondrial carrier family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • transporter activity
  • responsible for the uptake or efflux of adenine nucleotides into or from mitochondria and hence for the variation in the matrix adenine nucleotide content (which changes in physiopathological situations)
  • play an important role in modulating cell-death pathways by influencing the opening of the mPT pore through regulation of the calcium-buffering capacity of mitochondria and regulation of the total mitochondrial adenine content
  • exerts a negative feedback control between cellular Ca(2+) overload and mitochondrial permeability transition (mPT)-dependent cell death
  • importance of SLC25A24 in the regulation of body fat mass and adipogenesis
  • responsible for transporting ATP across the mitochondrial inner membrane
  • function of SLC25A24 is important for mitochondrial activities that depend on adenine nucleotides, such as gluconeogenesis and mitochondrial biogenesis
  • encodes a mitochondrial inner membrane ATP-Mg/Pi carrier
  • allows an electro-neutral and reversible exchange of ATP-Mg and phosphate between the cytosol and mitochondria, which is required for maintaining optimal adenine nucleotide levels in the mitochondrial matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS mitochondrial transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ion Ca2+ binding
  • ATP-Mg binding
  • phosphate binding
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GCMS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS