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FLASH GENE
Symbol SPSB3 contributors: SGE/mct - updated : 08-12-2020
HGNC name splA/ryanodine receptor domain and SOCS box containing 3
HGNC id 30629
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one B30.2/SPRY domain
  • one SOCS domain
  • HOMOLOGY
    interspecies homolog to murine Spsb3 (89.3pc)
    homolog to rattus Spsb3 (89.6pc)
    Homologene
    FAMILY
  • SPSB family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in intracellular signaling cascade
  • may be a substrate recognition component of SCF-like ECS E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins
  • SPSB3-mediated SNAI1 degradation has a vital role in regulating EMT and cancer progression
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • interacting with the Elongin BC complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MET
  • SPSB3 is a novel E3 ligase component that targets SNAI1 into polyubiquitination and degradation in response to GSK3B phosphorylation of SNAI1
  • paralogs SPSB1 and SPSB4, but not SPSB2 and SPSB3, can interact with and facilitate NR1D1 ubiquitination and degradation and regulate circadian clock periodicity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in esophageal squamous cell carcinoma tissues, indicates lymph node metastasis
    constitutional     --over  
    in Parkinson disease (PD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS