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FLASH GENE
Symbol RASGEF1A contributors: mct - updated : 30-08-2011
HGNC name RasGEF domain family, member 1A
HGNC id 24246
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RasGEF-N domain
  • C-terminal CDC25-Ras exchange motif domain
    • HOMOLOGY
    Homologene
    FAMILY RasGEF1 family of proteins
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • having guanyl-nucleotide exchange factor activity
  • RASGEF1A and RASGEF1B function as very specific exchange factors for RAP2A, a member of the Rap subfamily of Ras-like G-proteins
  • guanine nucleotide exchange factor that discriminate between Rap GTP-binding proteins and mediate RAP2A-specific nucleotide exchange
    • CELLULAR PROCESS nucleotide, repair, nucleotide excision repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • four candidate target genes for NO66, SBNO1, TGFBRAP1, RIOK1, and RASGEF1A, which were the most significantly induced by exogenous NO66 expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS