basic FUNCTION
| may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination |
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CPSF4 and WDR33 directly contact AAUAAA |
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is the large CPSF subunit participating in recognition of the polyadenylation signal |
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CPSF1 functions as an essential scaffold and preorganizes CPSF4 and WDR33 for high-affinity binding to AAUAAA |
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both CPSF4 and WDR33 are required for high-affinity binding of the AAUAAA polyadenylation signal (PAS) RNA, while these two proteins alone and their binary complexes with CPSF1 have much lower affinity for the RNA |