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FLASH GENE
Symbol RHOXF2 contributors: mct - updated : 19-06-2020
HGNC name Rhox homeobox family, member 2
HGNC id 30011
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a homeobox domain
HOMOLOGY
interspecies ortholog to murine Rhox gene cluster (one or more members)
Homologene
FAMILY
  • paired-like homeobox family
  • PEPP subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulating downstream genes and biological events in the testis
  • having conserved roles in the reproductive tract
  • testis-restricted or testis-selective protein (Hofmann 2008)
  • is involved in carcinogenesis
  • is a fast-evolving homeobox gene in primates
  • its expression increases in the second trimester during fetal testes development when gonocytes differentiate into prespermatogonia
  • potential role of RHOXF2 in regulating function of membrane and microtubules
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development , reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer , and was correlated with higher stages of tumors
    tumoral     --over  
    in some leukemia cell lines and a variety of human cancer samples including colon and lung cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • ODF4 and RHOXF2 are proposed as putative breast cancer biomarkers at the transcript level
  • Therapy target
    ANIMAL & CELL MODELS