basic FUNCTION
| may play a key role in extracellular phospholipid transport |
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involved in modulation of HDL particles (prebeta-HDL) |
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converting HDL into larger and smaller particles |
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involved in cholesterol metabolism |
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novel anti-inflammatory function of PLTP in the lung, suggesting that proteolytic cleavage of PLTP by CTSG may enhance the injurious inflammatory responses that occur in chronic obstructive pulmonary disease (COPD) |
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role of PLTP and CETP in atherogenesis |
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PLTP may play a role in the first step of lipoprotein assembly, but it is likely that PLTP plays an auxiliary role in both the steps, as both steps depend on the availability of phospholipids |