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FLASH GENE
Symbol PLTP contributors: mct - updated : 17-05-2016
HGNC name phospholipid transfer protein
HGNC id 9093
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide of 17 aa
  • a conserved C terminal required for anchoring lipoprotein particles
  • six potential N-glycosylation sites (Asn-X-Ser) (Qu 2006)
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Pltp (82.7 pc)
    homolog to rattus Pltp (82.1 pc)
    intraspecies homolog to LBP,highly
    Homologene
    FAMILY
  • BPI/LBP/Plunc superfamily
  • LBP/BPI/CETP family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may play a key role in extracellular phospholipid transport
  • involved in modulation of HDL particles (prebeta-HDL)
  • converting HDL into larger and smaller particles
  • involved in cholesterol metabolism
  • novel anti-inflammatory function of PLTP in the lung, suggesting that proteolytic cleavage of PLTP by CTSG may enhance the injurious inflammatory responses that occur in chronic obstructive pulmonary disease (COPD)
  • role of PLTP and CETP in atherogenesis
  • PLTP may play a role in the first step of lipoprotein assembly, but it is likely that PLTP plays an auxiliary role in both the steps, as both steps depend on the availability of phospholipids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text phospholipid transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeted by LXR, expressed by macrophages in atherosclerotic lesions
  • APOE/PLTP interactions can be modulated by the conformation and lipidation state of APOE
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    acute elevation activity destabilizes atherosclerotic lesions and aggravates pre-existing atherosclerosis (Moerland 2008)
    constitutional     --over  
    activity increased in type 2 diabetic patients with or without coronary artery disease (Attia 2007)
    constitutional somatic mutation      
    in hypoalphalipoproteinemia (Aouizerat 2006, Engler 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    expressed in plasma from transgenic mice and contributing to formation of pre beta HDL