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FLASH GENE
Symbol D2HGDH contributors: mct - updated : 23-01-2015
HGNC name D-2-hydroxyglutarate dehydrogenase
HGNC id 28358
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
FAD domain
HOMOLOGY
interspecies homolog to murine D2hgdh
Homologene
FAMILY FAD-binding oxidoreductase/transferase type 4 family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
basic FUNCTION
  • converting D-2-hydroxyglutarate into 2-ketoglutarate
  • D-2-hydroxyglutarate dehydrogenase, which converts D-2HG to 2-oxoglutarate and decreases the level of D-2-hydroxyglutaric acid (D-2HG)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) D2HA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS