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FLASH GENE
Symbol LRRC47 contributors: mct - updated : 28-06-2021
HGNC name leucine rich repeat containing 47
HGNC id 29207
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven leucine-rich repeats
  • conjugated PhosphoP
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Lrrc47 (87.7pc)
    homolog to rattus Lrrc47 (91.9pc)
    Homologene
    FAMILY
    CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • aminoacyl-tRNA synthetase
  • may be suggests involvement in cytoskeleton, signaling, and chaperone system abnormalities (Shin 2004)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer of two alpha and two beta chains
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • EIF1AD and LRRC47 bind to late pre-40S particles near RIOK1 and the central rRNA helix 44
  • cell & other
    REGULATION
    Other acetylated protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly decreased (P < 0.05) in fetal Down's syndrome brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS