basic FUNCTION
| may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway |
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playing a role in transducing CDC42 signals directly to the nucleus |
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involved in extracellular matrix-induced integrin signaling, ultimately activating signaling processes like the activation of the small GTPase Rac |
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tyrosine kinase linked to many components involved in vesicle dynamics including clathrin, AP2 and synaptojanin-1 |
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ability of TNK2 to modulate AXL and perhaps anaplastic lymphoma kinase (altered in anaplastic large cell lymphomas) might explain why TNK2 can promote metastatic and transformed behavior in a number of cancers |
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nonreceptor tyrosine kinase that participates in tumorigenesis, cell survival, and migration |
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by positively regulating pro-survival factors such as AKT and AR, TNK2 is emerging as a critical player in cancer biology |