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FLASH GENE
Symbol ZBTB4 contributors: SGE - updated : 24-08-2009
HGNC name zinc finger and BTB domain containing 4
HGNC id 23847
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one BTB/POZ domain, POZ domain
  • 6 C2H2-type zinc fingers
  • Kaiso-like zinc fingers
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to rattus Zbtb4 (88.6pc)
    homolog to murine Zbtb4 (89.2pc)
    intraspecies homolog to ZBTB33
    Homologene
    FAMILY Kaiso-like proteins family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be involved in transcriptional regulation
  • able to repress transcription in a methyl-dependent manner, yet their tissue-specific expression pattern suggests nonoverlapping functions
  • represses transcription of CDKN1A and controls the cellular response to TP53 activation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer or heterodimerizing with ZBTB38 (Filion 2006)
  • INTERACTION
    DNA bind methylated DNA
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • bind methylated CGCGs through its three Kruppel-like C2H2 zinc fingers
  • associates with the Sin3/histone deacetylase co-repressor and represses expression of CDKN1A as part of a heterodimeric complex with ZBTB17
  • shares with ZBTB33 the ability to bind both methylated DNA and the KBS (Kaiso binding site)
  • with CDKN1A may have critical oncogenic functions independent of the TP3 status of a cell
  • cell & other
    REGULATION
    Other phosphorylated by HIPK2 and down-regulated (Yamada 2009)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in advanced stages of multiple tumours
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS