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FLASH GENE
Symbol ANKRD12 contributors: mct/npt - updated : 26-09-2009
HGNC name ankyrin repeat domain 12
HGNC id 29135
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five ankyrin repeats
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text colocalized with histone deacetylases
    basic FUNCTION
  • may be recruiting HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the PAS region of the p160 coactivators
  • interacting with histone deacetylases
  • also interact with the co-activator TADA3L (repress TADA3L-mediated transcriptional co-activation on nuclear receptors) (Li 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS