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FLASH GENE
Symbol MORC4 contributors: mct/npt - updated : 07-10-2009
HGNC name MORC family CW-type zinc finger 4
HGNC id 23485
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CW-type zinc finger
  • nuclear localisation signals
  • a nuclear matrix-binding domain, together with a coiled-coil region
  • a HATPase-C domain (Liggins 2007)
  • HOMOLOGY
    interspecies homolog to murine Zcwcc2
    Homologene
    FAMILY
  • MORC family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potential lymphoma biomarker, whose overexpression may contribute to the immunological recognition of MORC4 by a subgroup of (diffuse large B-cell lymphoma) DLBCL patients (Liggins 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Zn2+
  • ATP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-germinal centre-derived DLBCL (diffuse large B-cell lymphoma) and Hodgkin lymphoma cell lines, compared with germinal centre-derived DLBCL cell lines and normal B cells (Liggins 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS