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FLASH GENE
Symbol MORC2 contributors: mct - updated : 17-07-2017
HGNC name MORC family CW-type zinc finger 2
HGNC id 23573
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CW-type zinc finger
  • a PRD domain, dispensable for the protein stability and subcellular localization of MORC2, but depletion of the PRD domain substantially suppressed MORC2-mediated migration, invasion, and metastasis
  • derived PHD finger domain and a conserved GHKL-type ATPase module, is a physiological substrate of p21-activated kinase 1 (PAK1), an important integrator of extracellular signals and nuclear processes
  • HOMOLOGY
    interspecies ortholog to murine Morc2a
    Homologene
    FAMILY Microrchidia (MORC) family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • involved in several nuclear processes, including transcription modulation and DNA damage repair
  • cytosolic function of MORC2 in lipogenesis, adipogenic differentiation, and lipid homeostasis by regulating the activity of ACLY
  • regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis
  • essential gene required for epigenetic silencing by the HUSH complex, and HUSH recruits MORC2 to target sites in heterochromatin
  • chromatin remodeling protein with emerging roles in the regulation of DNA damage response and gene transcription
  • promotes breast cancer invasion and metastasis through its PRD domain-mediated interaction with CTNND1
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • PAK1-MORC2 axis is likely critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interaction between MORC2 and adenosine triphosphate (ATP)-citrate lyase (ACLY), an enzyme that catalyzes the formation of acetyl-coA and plays a central role in lipogenesis, cholesterogenesis, and histone acetylation
  • MORC2 down-regulated CDKN1A by recruiting HDAC1 to the CDKN1A promoter, in a TP53-independent manner
  • MORC2 enhanced the recruitment of EZH2, which promoted the tri-methylation of H3K27, leading to the transcriptional repression of SORBS2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CMT2Z , DDGRM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS