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FLASH GENE
Symbol EEF1AKNMT contributors: mct - updated : 13-11-2019
HGNC name eEF1A lysine and N-terminal methyltransferase
HGNC id 24248
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two distinct MTase domains targeting the N terminus and Lys55 of EEF1A, respectively
  • HOMOLOGY
    Homologene
    FAMILY
  • methyltransferase superfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text localization of EEF1AKNMT in the cytoplasm, mitochondria, and nucleus
    basic FUNCTION
  • S-adenosylmethionine-dependent methyltransferase activity
  • is a tumor suppressor and might provide promising approaches for bladder cancer treatment and prevention
  • having antiapoptotic activity and playing a role in carcinogenesis
  • facilitates the INSL3 production in testicular Leydig cells that is essential for transabdominal testis migration
  • EEF1AKNMT inhibition may likely constitute a targetable vulnerability of tumors driven by aberrant RAS signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • loss of EEF1AKNMT function alters translation dynamics and results in changed translation rates of specific codons
  • EEF1AKNMT-catalyzed EEF1A methylation increases EEF1A intrinsic GTPase activity in vitro and protein production in cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in bladder cancer tissues
    tumoral     --over  
    significantly higher in breast cancer tissues than in normal breast tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate for applications in early diagnosis and prevention of some cancers
  • Marker
  • may be a potential biomarker for recurrence of breast cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • male Mettl13+/- mouse developed bilateral intraabdominal cryptorchidism, suggesting defective Insl3 production by fetal Leydig cells