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FLASH GENE
Symbol LZTS3 contributors: npt/mct - updated : 26-10-2018
HGNC name leucine zipper tumor suppressor family member 3
HGNC id 30139
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Prosapip1
    homolog to rattus Prosapip1
    intraspecies homolog to human KIAA0341
    homolog to significant sequence homology with the PSD protein LZTS1
    Homologene
    FAMILY
  • ProSAPs/Shanks family
  • leucine zipper tumor suppressor (LZTS) protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text co-localizes with ProSAP2/Shank3 in excitatory spines and synapses
    basic FUNCTION
  • have a major scaffolding function for components of the postsynaptic density (PSD) of excitatory brain synapses
  • is indeed involved in promoting the maturation of dendritic spines—most probably via regulating SPAR levels at the PSD
  • fulfill specific molecular functions at the PSD to guarantee the proper maturation of excitatory spine synapses
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text cell growth and/or maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind and recruit SIPA1L1 to synapses with a central coiled-coil region that harbors a leucine zipper motif
  • interaction partner of the well-known PSD protein SHANK3 and SPAR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS