Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSPA13 contributors: mct - updated : 20-08-2015
HGNC name heat shock protein 70kDa family, member 13
HGNC id 11375
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal ATPase domain
  • an unique hydrophobic signal sequence
  • without C-terminal DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY stress 70 chaperone family member
    CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • involved in the processing of cytosolic and secretory proteins
  • Hsp70-like protein, playing a role in regulating cell cycle and cell death events
  • has likely a role in cell survival via modulation of the TRAIL-mediated cell death pathway
  • novel role of HSPA13 in the regulation of pHi through site-specific interactions with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • may play a role in pHi regulation at times of cellular stress by enhancing the recovery from intracellular acidification
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is interacting with SLC4A4 at the N-terminal (amino acids 96-440) region
  • site-specific interactions of HSPA13 with SLC4A4 and SLC9A1 and subsequent modulation of membrane transporter expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility susceptibility to gastric cancer
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    corresponding disease(s)
    Susceptibility to gastric cancer
    Variant & Polymorphism SNP increasing the risk of gastric cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS