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FLASH GENE
Symbol GNL2 contributors: mct - updated : 16-02-2022
HGNC name guanine nucleotide binding protein-like 2 (nucleolar)
HGNC id 29925
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • MMR1/HSR1 GTP-binding protein family
  • NOG2 subfamily
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • is a regulatory GTPase that monitors pre-60S maturation, with release from its placeholder site linked to recruitment of the nuclear export machinery
  • GNL2 (ngp-1) and SEC13 (npp-20), are required for Nonsense-mediated mRNA decay (NMD) in human cells
  • nucleolar proteins GNL2 and GNL3 have similar but non-overlapping roles in the final maturation or nucleolar release of 60S ribosomal subunits
  • MKI67, GNL2, and MDN1 play an important role in organizing the RNAmetasome network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • promotes cell cycle progression through the activation of the TP53/CDKN1A pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a promising prognosis biomarker for LIHC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    GNL2 could be a promising treatment for LIHC (liver hepatocellular carcinoma)
    ANIMAL & CELL MODELS