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FLASH GENE
Symbol HACD3 contributors: mct - updated : 03-02-2020
HGNC name 3-hydroxyacyl-CoA dehydratase 3
HGNC id 24175
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to murine Ptplad1 (90.3pc)
Homologene
FAMILY
CATEGORY signaling
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,nuclear envelope
basic FUNCTION
  • potentiating different effects of the small GTPase RAC1, such as c-Jun N-terminal kinase activation
  • transcriptional activity of nuclear factor kappaB (NF-kappaB
  • overexpressed HACD3 exhibited weak activity in saturated and monounsaturated fatty acids (FAs) elongation pathways
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with RAC1 (component of RAC1-signaling pathways leading to the modulation of gene expression)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSP90AA1-dependent chaperone pathway incorporating HACD3 is involved in protein folding in the membranous web for the circumvention of the UPR and that it facilitates HCV replication
  • ATIC, which is a rate-limiting enzyme in the de novo purine biosynthesis pathway, and PTPLAD1 are associated with insulin receptor (INSR) internalization
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS