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FLASH GENE
Symbol DIMT1 contributors: mct - updated : 06-11-2019
HGNC name DIMT1 rRNA methyltransferase and ribosome maturation factor
HGNC id 30217
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY rRNA adenine N-6-methyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,matrix
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleolus
basic FUNCTION
  • dimethylating two adjacent adenosines in the loop of a conserved hairpin near the 3'end of 16s rRNA in the 30s particle
  • DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    rRNA processing, rRNA modification
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    correlated closely with differentiation, invasion, lymph node metastasis, distant metastasis in gastric carcinoma
    tumoral     --over  
    gradually with multiple myeloma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a useful molecular biomarker to predict tumor progression and prognosis in patients with gastric carcinoma (28601661)
  • is a novel diagnostic marker for all molecular subtypes of multiple myeloma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    therapeutic target for all molecular subtypes of multiple myeloma
    ANIMAL & CELL MODELS