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FLASH GENE
Symbol HACL1 contributors: np - updated : 19-01-2005
HGNC name 2-hydroxyacyl-CoA lyase 1
HGNC id 17856
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a thiamine pyrophosphate-binding consensus domain is present in the C-terminal part
  • HOMOLOGY
    Homologene
    FAMILY
  • TPP enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • catalyzing the carbon-carbon bond cleavage during alpha-oxidation of 3-methyl-branched fatty acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • one thiamine pyrophosphate and 1 magnesium ion per subunit
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS