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FLASH GENE
Symbol HNRNPL contributors: mct - updated : 12-01-2016
HGNC name heterogeneous nuclear ribonucleoprotein L
HGNC id 5045
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycine- and proline-rich domains
  • two segments of approximately 80 amino acids each that are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other hnRNP and snRNP proteins
  • four RNA recognition motif (RRM) domains
  • HOMOLOGY
    intraspecies paralog to HNRNPLL
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a major role in the formation, packaging, processing, and function of mRNA
  • playing a role in in transcriptional regulation
  • PTBP1 and HNRNPL are positive regulators of SLC7A1 mRNA translation via the internal ribosome entry site (IRES) under stress conditions that cause a global decrease of protein synthesis
  • PTBP1 and an HNRNPL, promote the efficient translation of SLC7A1 mRNA during amino acid starvation
  • can regulate alternative mRNA splicing in diverse ways, binding to exonic or intronic sites and acting as either an activator or repressor
  • is a key factor involved in the spermatogenesis
  • HNRNPL regulates T cell differentiation and migration by regulating pre-TCR and chemokine receptor signaling
  • HNRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition
  • HNRNPLL and HNRNPL have overlapping, but distinct, expression patterns and functional consequences
  • HNRNPLL has a greater silencing activity than HNRNPL
  • HNRNPL and HNRNPLL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
  • a multifunctional RNA-binding protein that is involved in many different processes, such as regulation of transcription, translation, and RNA stability
  • HNRNPL is a new regulator for CD44 V10 exon splicing
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the heterogenous nuclear ribonucleoprotein (HNRNP) complexes
  • INTERACTION
    DNA
    RNA
  • specifically binds to RNAs containing CA repeats or CA-rich clusters
  • small molecule
    protein
  • with APE1
  • association with VEGF mRNA under hypoxia (may play an important role in hypoxia-induced post-transcriptional
  • regulation of VEGF mRNA expression)
  • with PTBP1
  • HNRNPL is an essential component of CAMK4-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role
  • interaction between HNRNPL and CA repeats of BCL2 mRNA participates in destabilizing BCL2 mRNA
  • HNRNPL and HNRNPLL thus antagonistically modulate PTB-mediated splicing suppression of exon P3A of CHRNA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS