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FLASH GENE
Symbol HNRNPL contributors: npt - updated : 20-01-2005
HGNC name heterogeneous nuclear ribonucleoprotein L
HGNC id 5045
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycine- and proline-rich domains
  • two segments of approximately 80 amino acids each that are weakly related to each other and to the ribonucleoprotein consensus sequence-type RNA-binding domains of other hnRNP and snRNP proteins
  • three RNA recognition motif (RRM) domains
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a major role in the formation, packaging, processing, and function of mRNA
  • playing a role in in transcriptional regulation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the heterogenous nuclear ribonucleoprotein (HNRNP) complexes
    • INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • with APE1
  • association with VEGF mRNA under hypoxia (may play an important role in hypoxia-induced post-transcriptional
    • regulation of VEGF mRNA expression)
  • with PTBP1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS