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FLASH GENE
Symbol TMED4 contributors: KTN/npt - updated : 18/11/2008
HGNC name transmembrane emp24 protein transport domain containing 4
HGNC id 22301
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 29 aa signal peptide
  • one gold (Golgi dynamics) domain
  • a coiled-coil region
  • a transmembrane domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TMED4 (96.3 pc)
    homolog to chimpanzee TMED4 (99.6 pc)
    homolog to cow TMED4 (94.3 pc)
    homolog to rattus Tmed4 (94.7 pc)
    homolog to murine Tmed4 (94.7 pc)
    Homologene
    FAMILY
  • EMP24/GP25L family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus
    text single-pass type I membrane protein
    basic FUNCTION
  • involved in vesicular protein trafficking between the ER and the Golgi
  • involved in the positive regulation of I-kappaB kinase/NF-kappaB cascade
  • may play a critical role in regulation of heat-shock response and apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    I-kappaB kinase/NF-kappaB cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by ER-specific stress, heat shock, and oxidative stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS