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FLASH GENE
Symbol ABCE1 contributors: mct - updated : 17-01-2017
HGNC name ATP-binding cassette, sub-family E (OABP), member 1
HGNC id 69
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a unique N-terminal region with eight conserved cysteines, predicted to coordinate iron-sulfur clusters (N-terminal Fe-S binding domain)
  • eight cysteine, histidine and lysine residues
  • twin ABC ATPase domains, which are arranged in a head-to-tail orientation via a flexible linker and hinge region
  • two essential diamagnetic [4Fe-4S]2+ clusters
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Abce1
    Homologene
    FAMILY ATP binding cassette superfamily, subfamily E (OABP)
    CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • playing a critical role for proper assembly of the HIV-1 capsid
  • playing a role in RNase L inhibition, human immunodeficiency virus (HIV1)capsid maturation, translation initiation, and ribosome biosynthesis
  • role in eukaryotic translation has been linked to several stages during protein synthesis, including initiation and most recently termination and ribosome recycling
  • required for the assembly of the HIV and SIV gag polypeptides
  • promotes eukaryotic ribosomal recycling over a wide range of Mg(2+) concentrations
  • play an important role in the pathogenesis of human small cell lung cancer cell
  • essential and highly conserved protein that requires notoriously ROS-labile cofactors (Fe-S clusters) for its functions in protein synthesis
  • its function is a primary target of ROS action
  • is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of RNASEL
  • ribosome-recycling factor important for translation termination in mammalian cells
  • is crucial for ribosome recycling and controls ribosome homeostasis
  • is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression
  • erythroid cells and platelets ribosomes accumulate as a result of the natural loss of the ribosome recycling factor ABCE1 during terminal differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Rnase4 inhibitor, 2', 5'-oligoisoadenylate dependent, interferon regulated pathway
    a component
  • ABCE1/Pelota/HBS1L also dissociated vacant 80S ribosomes, which stimulated 48S complex formation, suggesting that Pelota/HBS1L have an additional role outside of stable secondary structures (NGD)
  • heterodimer with RNASEL, ABCE1 protein inhibits the IFN-depended RNASEL system and regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis
  • INTERACTION
    DNA
    RNA
    small molecule playing a role in RNase L inhibition, human immunodeficiency virus (HIV) capsid maturation, translation initiation, and ribosome biosynthesis
    protein
  • interact with translation initiation factors, eIF2, eIF3, eIF5, the 40 S ribosomal subunit, and several ribosomal RNAs
  • UBASH3A bind to ABCE1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion
  • interacting with PELO/HBS1L (Pelota/HBS1L induced dissociation of elongation complexes and release of peptidyl-tRNA, but only in the presence of ABCE1)
  • RNASEL inhibitor, ABCE1 is currently recognized as an essential translation factor involved in several stages of eukaryotic translation and ribosome biogenesis
  • ABCE1 interacts with the cytoskeleton protein actin and increases cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    is correlated with aggressive growth and metastasis in lung cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may be used as a potential target of gene therapy for small cell lung cancer
    ANIMAL & CELL MODELS