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FLASH GENE
Symbol HILPDA contributors: mct - updated : 23-01-2012
HGNC name hypoxia inducible lipid droplet-associated
HGNC id 28859
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,granule
basic FUNCTION
  • involved in the response to stress
  • implicated in canonical Wnt signaling, both as target and activator
  • decorates the hemimembrane of lipid droplets, whose number and size increase on hypoxic inhibition of fatty acid beta-oxidation, and colocalizes with the lipid droplet proteins adipophilin
  • could be detected in atherosclerotic arteries and fatty liver disease
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with DBN1, and HILPDA, SETMAR, is a direct target of the SOX11 protein (are direct transcriptional targets of the SOX11 protein)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    aberrantly expressed in cervical cancer (UCC) and endometrial cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a marker for early detection of ovarian clear cell adenocarcinomas or for prediction of response to chemotherapy, but its expression does not predict survival of patients with clear cell adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS