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FLASH GENE
Symbol MOGAT2 contributors: mct - updated : 11-01-2017
HGNC name monoacylglycerol O-acyltransferase 2
HGNC id 23248
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • catalyzing the synthesis of diacylglycerol, a precursor of triacylglycerol
  • playing a major role in the absorption of dietary fat in the intestine by catalyzing the resynthesis of triacylglycerol in enterocytes
  • in the intestine, plays a major role in the absorption of dietary fat by catalyzing the resynthesis of triacylglycerol in enterocytes
  • is a key determinant of energy metabolism in response to dietary fat, suggesting that the inhibition of this enzyme may prove to be a useful strategy for treating obesity and other metabolic diseases associated with excessive fat intake
  • in the intestine plays an indispensable role in enhancing metabolic efficiency but also raise the possibility that MOGAT2 in other tissues may contribute to the regulation of energy metabolism
  • adult-onset MGAT2 deficiency mitigates metabolic disorders induced by high-fat feeding and MGAT2 modulates early postnatal nutrition and may program metabolism later in life
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DGAT2 interacted with monoacylglycerol acyltransferase MOGAT2, an enzyme that catalyzes the synthesis of diacylglycerol
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    obesity  
    blocking MOGAT activity in enterocytes is a feasible approach to inhibit fat absorption and treat obesity
    ANIMAL & CELL MODELS
  • mice lacking the gene MOGAT2, which codes for an MGAT highly expressed in the small intestine, are resistant to obesity and other metabolic disorders induced by high-fat feeding