basic FUNCTION
| playing an essential role for S phase entry |
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operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2 |
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replication stress-induced recruitment of HELB to chromatin is independent of checkpoint signaling but correlates with the level of replication protein A (RPA) recruited to chromatin |
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facilitates cellular recovery from replication stress and promotes homologous recombination |
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role of HELB in the beginning of the DNA synthesis |
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acts independently of TP53BP1 and is exported from the nucleus as cells approach S phase, concomitant with the upregulation of DNA end resection |