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FLASH GENE
Symbol EXOSC10 contributors: mct - updated : 17-09-2018
HGNC name exosome component 10
HGNC id 9138
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two potential glycosylation sites
  • multiple potential phosphorylation sites
  • one 3'-5' exonuclease domain
  • one HRDC domain
  • HOMOLOGY
    interspecies homolog to murine Exosc10
    Homologene
    FAMILY
    CATEGORY enzyme , RNA associated , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • required for the 3' processing of the 7S pre-RNA to the mature 5.8S rRNA
  • has a 3'-5' exonuclease activity
  • although not required for exosome stability, EXOSC10 and EXOSC9 are involved in mRNA degradation, either as essential subunits of a functional exosome complex or as exosome-independent proteins
  • may play a more prominent role in processing, as in degradation of coding and noncoding RNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the mRNA decay complex (LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CCRN4L, UPF1, UPF2, UPF3B)
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • PARN increased TERC levels by deadenylating TERC, thereby limiting its degradation by EXOSC10
  • interaction of CELF1 and EXOSC10 was RNA-independent and nucleus specific
  • was likely required for CELF1-mediated GJA1 mRNA degradation
  • interaction between SMNDC1 and the exosome core is mediated by MTREX and EXOSC10, a catalytic component of the nuclear exosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS