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FLASH GENE
Symbol MOGS contributors: mct/npt - updated : 25-02-2016
HGNC name mannosyl-oligosaccharide glycosidase
HGNC id 24862
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • (Arg)3 within the N-terminal domain contains ER targeting information but not required absolutely for ER localization
  • HOMOLOGY
    Homologene
    FAMILY
  • glycosyl hydrolase 63 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • removing specifically distal alpha1-2 linked glucose from the Glc (3), Man (9), GlcNAc (2) precursor after its en bloc transfer from dolichyl diphosphate to a nascent polypeptide chain in the endoplasmic reticulum
  • cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor
  • first enzyme in the processing pathway of N-linked oligosaccharide
  • is involved in the trimming of N-glycans
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    first step in the N-linked oligosaccharide processing pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG2B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS