basic FUNCTION
| GTPase-activating protein for the ADP ribosylation factor family |
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involved in controlling vesicle trafficking, adhesion |
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and cytoskeletal organization |
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may be acting as a scaffold protein to facilitate c-Src-dependent activation of MAP2K1-MAPK1/MAPK2 in response to both GPCRs and TKRs |
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playing a critical role in spine and synapse formation |
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regulating protrusive activity in cells by phosphorylation of serine 709 in GIT1 |
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may play a role for cytoskeletal reorganization during platelet aggregation |
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play an important role in initiating the disassembly of focal adhesions |
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multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking |
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essential mediator for VEGFA-induced endothelial cells podosome formation and cell migration via PLCgamma |
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critical role for GIT1 in pulmonary vascular development by regulating VEGF-induced PLCG and ERK1/2 activation |
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with ARHGEF7 regulate HGF-induced lamellipodia formation and WASF2 transport |
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key regulator of bone mass by regulating osteoclast function |
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multi-function scaffold protein, regulator of mitochondrial biogenesis and function, which is necessary for postnatal cardiac maturation |
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plays an important role in NOS3 function, in both normal and abnormal pathophysiologic states |
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could be important in vascular signaling and disease |
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multifunctional protein that acts as a GTPase-activating protein (GAP) for Arf GTPases, as well as serves as a scaffold for a number of different signaling proteins |
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multidomain protein GIT1 is involved in cytoskeletal rearrangements and cell motility |
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is known to be important for cell spreading and migration, processes which rely on paxillin trafficking and focal adhesion turnover |
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MAT2B and GIT1 form a scaffold, which recruits and activates MEK and ERK to promote growth and tumorigenesis |
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is a novel mediator of vascular remodeling by regulating vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis through phospholipase C gamma and extracellular signal-regulated kinase 1/2 signaling pathways |
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GIT1, GIT2, ARHGEF7 and RHOJ all colocalised in focal adhesions and depended on each other for their recruitment to focal adhesions |
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GIT1 and ARHGEF7 are involved in Ag-induced chemotaxis, a possible mecanism of concerted action of tyrosine kinases, GIT1/ARHGEF7 proteins, and Ca(2+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells |
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distinct roles for GIT1 and GIT2 in regulating neurotransmitter release strength, with GIT1 as a specific regulator of presynaptic release probability |
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GIT1/ARHGEF7 signaling proteins with PAK1 kinase represent a novel regulatory mechanism of microtubule nucleation in interphase cells |
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GIT1 and GIT2, are GTPase-activating proteins (inactivators) for the ADP-ribosylation factor (Arf) small GTP-binding proteins, and function to limit the activity of Arf proteins |