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FLASH GENE
Symbol OSMR contributors: mct - updated : 11-03-2020
HGNC name oncostatin M receptor
HGNC id 8507
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four extracellular fibronectin type III-like (FNIII) domains, regions critical for receptor dimerization and function
  • a WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding
  • a box 1 motif is required for JAK interaction and/or activation
  • HOMOLOGY
    Homologene
    FAMILY IL6 family of cytokines
    CATEGORY signaling cytokine , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • play a role in signal transduction (Scotto 2008)
  • OSMR may act as a tumour suppressor in colorectal carcinoma and OSMR methylation may play an important role in non-invasive colorectal cancer
  • adipocyte OSM&
  • 8315;OSMR signaling plays a role in adipose tissue CXCL12 production and may mitigate its effects on adipose tissue homeostasis
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of OSM receptor complex (a heterodimer of GP130 or IL6ST and OSMR)
  • part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family
  • OSM and interleukin-31 (IL31) are two cytokines belonging to the IL6 family which share a common signaling receptor subunit, OSMR
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OSM is neuroprotective by recruiting OSMR in the setting of ischemic stroke
  • SMARCA4 and STAT3 coordinately regulate gene clustering and up-regulate GFAP and OSMR transcription
  • OSMR activates a non-redundant signaling pathway by recruitment of the adapter SHC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FPLCA
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    silencing inhibits the activation of the JAK/STAT3 signaling pathway, thereby suppressing the development of chronic autoimmune urticaria (CAU)
    tumoral     --over  
    in advanced cervical squamous cell carcinoma (SCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a biomarker candidate gene to predict prognosis of bladder cancer
  • Therapy target
    ANIMAL & CELL MODELS
  • mice, lacking the OSM receptor (Osmr) in adipocytes (OsmrFKO mice), exhibit derangements in adipose tissue, insulin sensitivity, and immune cell balance