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FLASH GENE
Symbol GSS contributors: mct - updated : 05-03-2011
HGNC name glutathione synthetase
HGNC id 4624
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycine residues in the G-loop maintaining loop flexibility essential for ligand binding and active site closure
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY eukaryotic GSH synthase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • essential tripeptide antioxidant, that protects against reactive oxygen species and participates in metabolism of drugs and carcinogens
  • involved in glutathione biosynthesis second step
  • plays an important role in defending the cell against reactive oxygen species
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    sulfur metabolism, glutathione biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by NFE2L2
    ASSOCIATED DISORDERS
    corresponding disease(s) GSS , GSDE
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS