basic FUNCTION
| negatively regulating the elongation of transcription |
|
by RNA polymerase II |
|
may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products |
|
modulates estrogen-dependent and independent transcription and suppresses the growth of breast cancer cells |
|
NELFB and BRCA1 may engage in common gene regulatory pathways to suppress breast cancer progression |
|
important role of NELFA, NELFB in controlling RNA polymerase II (Pol II) pausing in transcription |
|
helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes |
|
NELFA and NELFB are each shown to act independently as competitive decelerators at two steps after the site of glucocorticoid receptor (GR) action and before or at the site of reporter gene activity |