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FLASH GENE
Symbol CHTF8 contributors: mct/npt - updated : 09-04-2018
HGNC name CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
HGNC id 24353
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to zebrafish Dr.24240
homolog to xenopus Xl.105691
Homologene
FAMILY
  • CTF8 family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • may be implicated in tumorigenesis of kidney and prostate
  • involved in establishment of sister chromatid cohesion
  • CHTF8-RFC1 has additional important functions in preserving genome stability, besides its role in sister chromatid cohesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • C-terminal 23-AA stretch of CHTF18 was necessary for the trimeric association of complex CHTF18, DSCC1, and CHTF8 and was required for the stable interaction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CHTF18-DSCC1-CHTF8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA (Bermudez 2003)
  • CHTF18-RFC1 clamp loader contains a unique module in which the DSCC1-CHTF8 complex is bound to the C terminus of CHTF18 (the CHTF18-DSCC1-CHTF8 module)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    prostate and renal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS