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FLASH GENE
Symbol CALY contributors: mct - updated : 13-01-2015
HGNC name calcyon neuron-specific vesicular protein
HGNC id 17938
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • NEEP21 family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • type III membrane protein
  • localized to vesicular compartments within pre- and postsynaptic structures
  • basic FUNCTION
  • required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors
  • role for calcyon in clathrin-mediated endocytosis in brain
  • may have a role in potentiating calcium ion-dependent signaling
  • brain-specific D1-interacting protein involved in D1/D5 receptors calcium signaling
  • mobility and storage properties of calcyon-containing vesicles imply that they play a role in brain plasticity
  • endocytic protein that regulates clathrin assembly and clathrin-mediated endocytosis in the brain
  • plays potentially a specialized role in regulating activity-dependent removal of synaptic AMPARs
  • NSG1 and CALY play related, but distinct roles in regulating vesicle trafficking at synapses, and in neurons in general
  • neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis
  • stimulates clathrin-mediated endocytosis and endosomal targeting
  • NSG1 and CALY perform distinct roles in regulating receptor endocytosis, recycling, and degradation
  • balancing NSG1 and CALY expression and/or activity could be important for homeostasis in a variety of signaling pathways, and also lead to a novel therapeutic strategy for disorders like Alzheimer disease and schizophrenia
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs
  • regulates the subcellular distribution of AP3 adaptor protein and the targeting of AP3 cargoes
  • interacting directly with DRD1, and is implicated in various neuropsychiatric disorders including schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder
  • interacts with DLG4 and subsequently forms a ternary complex with DRD1 through DLG4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to deficit/hyperactivity disorder (ADHD)
    Variant & Polymorphism other haplotype C1 containing a risk allele for deficit/hyperactivity disorder
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS