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FLASH GENE
Symbol COMMD5 contributors: mct - updated : 14-04-2021
HGNC name COMM domain containing 5
HGNC id 17902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminus binding to the endosomal RAB5,
  • a mutated calcium-binding site (EF-hand motif)
  • four putative "leucine zipper" motifs
  • a nuclear receptor-binding domain
  • C terminus, including the COMMD domain, binds to the cytoskeletal scaffolding
  • HOMOLOGY
    Homologene
    FAMILY MURR1/COMMD1 family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs
  • likely accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation
  • only COMMD9 and its binding partner, COMMD5, have substantial effects on Notch
  • is crucial for the stability of the cytoskeleton
  • COMMD5 acts as an adaptor protein to coordinate endosomal trafficking and is important for EGFR transport and activity
  • as a versatile modulator of tumor progression
  • role for COMMD5 in the establishment and maintenance of the epithelial cell phenotype, suggesting a tumor suppressor function
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    Ca2+ regulated
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in several non-small cell lung cancer (NSCLC) cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS