basic FUNCTION
| suppressing NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs |
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likely accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation |
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only COMMD9 and its binding partner, COMMD5, have substantial effects on Notch |
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is crucial for the stability of the cytoskeleton |
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COMMD5 acts as an adaptor protein to coordinate endosomal trafficking and is important for EGFR transport and activity |
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as a versatile modulator of tumor progression |
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role for COMMD5 in the establishment and maintenance of the epithelial cell phenotype, suggesting a tumor suppressor function |