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FLASH GENE
Symbol PLXNB1 contributors: mct - updated : 14-01-2016
HGNC name plexin B1
HGNC id 9103
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Sema domain
  • three IPT/TIG domains
  • a RHO binding domain (B1RBD)
  • conjugated GlycoP , PhosphoP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to rattus Plxnb1 (87 pc)
    homolog to murine Plxnb1 (87.3 pc)
    intraspecies homolog to the hepatocyte growth factor receptor family
    Homologene
    FAMILY
  • calcium-dependent cell adhesion molecule family
  • plexin family
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • single-pass type I membrane protein
  • basic FUNCTION
  • acting as a receptor for SEMA4D
  • playing a role in RHOA activation and subsequent changes of the actin cytoskeleton
  • playing a role in axon guidance, invasive growth and cell migration
  • promoting binding of cytoplasmic ligands by the interaction with SEMA4D
  • having a role in prostate cancer progression
  • SEMA4D/PLXNB1 promotes the dephosphorylation and activation of PTEN through the RRas GAP activity, inducing growth cone collapse
  • SEMA4D/PLXNB1-mediated NFKB1 activation and IL8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells
  • role for PPLXNB1 in maintenance of melanocyte survival and proliferation in the skin, suggesting that SEMA4D and PLXNB1 act cooperatively with HGF and MET to regulate MET-dependent effects in human melanocytes
  • PLXNB1 and SEMA4D cooperate to promote perineural invasion in a RHOA/ROK-dependent manner
  • SEMA4D receptor PXNBB1 induces repulsion in axon and dendrites by functioning as a GTPase-activating protein (GAP) for RRAS and MRAS, respectively
  • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    text
  • positive regulation of axonogenesis
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • monomer
  • heterodimer with PLXNB2 after proteolytic processing
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding specifically to the GTP binding activated RAC1
  • binding to ARHGEF11, ARHGEF12, ERBB2, MET, MST1R, RND1, NRP1 and NRP2
  • binding to PLXNA1
  • interacting with SEMA4D (its ligand)
  • SEMA4D, enhances tumor cell motility through binding its receptor, PLXNB1, in pancreatic cancer
  • SEMA4D/PLXNB1-mediated MRas GAP activity regulates actin-based dendrite remodeling through RAPH1
  • binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD
  • SEMA4D act through its receptor PLXNB1 to regulate axon growth cone guidance, lymphocyte activation, and bone density
  • SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in localized and metastatic prostate carcinoma
    tumoral     --over  
    in prostate carcinoma
    tumoral     --over  
    significantly higher in serous ovarian carcinomas than in normal ovaries
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    might be a useful biomarker and/or a novel therapeutic target in ovarian carcinoma
    ANIMAL & CELL MODELS