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FLASH GENE
Symbol FBXO42 contributors: mct/npt - updated : 08-09-2009
HGNC name F-box protein 42
HGNC id 29249
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an F-box motif in the N terminus
  • a Kelch domain downstream of the F-box
  • four Kelch repeats
  • a CHORD domain
  • the TPR-like domain
  • the CASH domain
  • the SPRY domain (Sun 2009)
  • HOMOLOGY
    interspecies ortholog to murine Fbxo42
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex
  • promotes ubiquitination and degradation of TP53 (Sun 2009)
  • promotes TP53 turnover through assembly of an SCF complex, revealing a pathway for the control of TP53 degradation and providing a link between the SCF complex and TP53 regulation (Sun 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with SKP1, CUL1, and RBX1, the components of the SCF Complex, and may thus function via assembly of an SCF complex (Sun 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS