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FLASH GENE
Symbol CSNK1E contributors: - updated : 22-03-2007
HGNC name casein kinase 1, epsilon
HGNC id 2453
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a protein kinase domain
    • conjugated PhosphoP
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to chimpanzee CSNK1E (96.7 pc)
    homolog to rattus Csnk1e (99.3 pc)
    homolog to murine Csnk1e (98.8 pc)
    homolog to chicken CSNK1E (95.7 pc)
    intraspecies homolog to CSNKP
    Homologene
    FAMILY
  • Ser/Thr protein kinase family
  • casein kinase I subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • can phosphorylate a large number of proteins, like DVL1
  • participating in Wnt signaling
  • may act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2
  • retaining PER1 in the cytoplasm
  • inhibiting cytokine-induced granuloytic differentiation
    • CELLULAR PROCESS nucleotide, repair, base excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS circadian , development
    text putatively involved in DNA repair throught excision and recombination
    PATHWAY
    metabolism
    signaling signal transduction
    putatively involved in generation of complete dorsal axis and induction of genes that are direct targets of WWT signals
    a component
  • autophosphorylated
  • component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
    • protein
  • interacting directly with PER1 and PER2 which may lead to their degradation
  • interacting with SOCS3
    • cell & other
    REGULATION
    inhibited by autoinhibition relieved by phosphatases and limited proteolysis
    Other down-regulated during granulocytic differentiation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target for pharmaceutical compounds influencing circadian rhythms, sleep, and jet lag, as well as other physiologic and metabolic processes under circadian regulation (Lowrey, 2000)
    ANIMAL & CELL MODELS
    mammalian circadian mutation tau