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FLASH GENE
Symbol FRMD3 contributors: mct/npt - updated : 15-05-2019
HGNC name FERM domain containing 3
HGNC id 24125
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one FERM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • protein 4.1 superfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • critical growth regulator in the pathogenesis of meningiomas
  • playing a key role in erythrocytes in regulating the physical properties of mechanical stability and deformability in membranes by stabilizing the spectrin-actin interaction
  • putative tumour suppressor gene suggesting an important role in the origin and progression of lung cancer (Haase 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in primary non-small cell lung carcinoma (Haase 2007)
    Susceptibility
  • susceptibility to diabetic nephropathy in type 1 diabetes
  • Variant & Polymorphism other
  • strong association was identified at the FRMD3 locus with susceptibility to diabetic nephropathy in type 1 diabetes
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS