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FLASH GENE
Symbol HAUS6 contributors: mct/npt/pgu - updated : 23-04-2020
HGNC name HAUS augmin-like complex, subunit 6
HGNC id 25948
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus LOC366403
Homologene
FAMILY
  • HAUS6 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • spindle-associated protein that promotes microtubule-dependent microtubule amplification and is required for efficient chromosome congression and segregation in mammalian cells
  • promotes microtubule-dependent microtubule amplification through its interaction with and recruitment of NEDD1, the targeting subunit of the gamma-tubulin ring complex
  • target of PLK1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes, and controls the relative contributions of these two pathways to microtubule polymerization during mitosis
  • controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of the HAUS complex that is essential for neuronal microtubule organization by ensuring uniform microtubule polarity in axons and regulation of microtubule density in dendrites
  • HAUS8/HAUS6 (433–955) forms a core scaffold within augmin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the NEDD1-gamma-tubulin complex and recruits this complex to the spindle, which, in turn, promotes microtubule polymerization
  • spindle-associated protein, promoting microtubule-dependent microtubule amplification through its interaction with and recruitment of NEDD1, the targeting subunit of the gamma-tubulin ring complex
  • holo-complex HAUS4 and HAUS1 are likely to be directly connected and together interact with HAUS8/HAUS6 (433–955) independent of other subunits
  • TMEM201 is involved in the recruitment of HAUS6 and TUBG1 to the mitotic spindle
  • cell & other
    REGULATION
    Other regulated by PLK1, a kinase essential for spindle assembly and its bipolarity
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS