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FLASH GENE
Symbol EXOC8 contributors: mct - updated : 22-09-2015
HGNC name exocyst complex component 8
HGNC id 24659
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PH domain
  • HOMOLOGY
    interspecies homolog to murine Exoc8 (94.3 pc)
    homolog to rattus Exoc8 (93.2 pc)
    Homologene
    FAMILY
  • EXO84 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • direct target of activated Ral implicated in the regulation of a variety of dynamic cellular processes
  • involved in the docking of exocystic vesicles with fusion sites on the plasma membrane
  • with RALB, are required for nutrient starvation-induced autophagocytosis, and RALB activation is sufficient to promote autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the exocyst complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with the GTP-bound forms of RALA and RALB via its PH domain
  • through direct binding to EXOC8, RALB induces the assembly of catalytically active ULK1 and Beclin1-VPS34 complexes on the exocyst, which are required for isolation membrane formation and maturation
  • RALA binding to EXOC2 “activates” the Exocyst, and subsequent binding of RALA to EXOC8 “inactivates” the Exocyst for such functions
  • deubiquitylated RALB promotes the assembly of the RALB-EXOC8-BECN1 complexes driving autophagosome formation
  • active RALA promotes the direct binding between the exocyst subunit EXOC8 and the PDZ domain of PARD6A through a non-canonical PDZ-binding motif
  • cell & other
  • binding lipids with phosphatidylinositol-3,4,5-trisphosphate groups
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS