protein
| interacting with the GTP-bound forms of RALA and RALB via its PH domain |
|
through direct binding to EXOC8, RALB induces the assembly of catalytically active ULK1 and Beclin1-VPS34 complexes on the exocyst, which are required for isolation membrane formation and maturation |
|
RALA binding to EXOC2 “activates” the Exocyst, and subsequent binding of RALA to EXOC8 “inactivates” the Exocyst for such functions |
|
deubiquitylated RALB promotes the assembly of the RALB-EXOC8-BECN1 complexes driving autophagosome formation |
|
active RALA promotes the direct binding between the exocyst subunit EXOC8 and the PDZ domain of PARD6A through a non-canonical PDZ-binding motif |