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FLASH GENE
Symbol FCHO1 contributors: mct - updated : 26-08-2015
HGNC name FCH domain only 1
HGNC id 29002
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one fch domain
  • one ww domain
  • a 90 AA motif, found in both FCHO1, FCHO2 and SGIP proteins, that directly binds TFAP2A
  • HOMOLOGY
    interspecies homolog to murine Fcho1
    Homologene
    FAMILY
    CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • playing a role in promoting maturation and morphological differentiation of cerebellar neurons
  • modulation in the expression level of FCHO1 and FCHO2, which have been reported to initiate clathrin-coated pits (CCPs), affects only the number of nucleations
  • FCHO1 and FCHO2 are early-arriving proteins at surface clathrin assemblies and are speculated to act as compulsory coat nucleators, preceding the core clathrin adaptor TFAP2A
  • FCHO1, FCHO2 and SGIP1 stabilize nascent endocytic pits by exposing membrane and cargo binding sites on TFAP2A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FCHO1/FCHO2 sculpt the initial bud site and recruit the clathrin machinery for clathrin-coated vesicle (CCV) formation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS