motifs/domains
| a bipartite nuclear localization signal at the N-terminus important in mediating nuclear transport, and two functional ubiquitin-interaction motifs (UIMs), UIM domain, which is a component of the BRCA1-A complex, interacting with Ub Lys-63 linkage conjugates and mediating the recruitment of BRCA1 to DSBs |
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a SIM domain that appears to bind specifically to SUMO2 conjugates, but not to SUMO1 |
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two potential CX(2)CX(11)HX(3)C-type zinc finger motifs at its carboxyl-terminal region |
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a central region (residues 233–399), the Abraxas-Interacting Region (AIR), mediates interaction with constituents of the BRCA1–UIMC1 protein complex |
basic FUNCTION
| may be functioning as an active repressor of transcription |
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required for DNA damage-induced BRCA1 translocation, and functions as a partner of BRCA1-BRCTD in response to DNA damage |
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plays a critical role in the regulation of estrogen receptor alpha and DNA damage response signaling |
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ubiquitin-interaction motif (UIM) containing protein that is associated with a BRCA1/BARD1 complex through its interaction with FAM175A |
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like many ubiquitin-binding proteins, had been reported to be ubiquitinated in a manner dependent on its UIM domains |
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UIMC1/BRCA1 complex, is required for efficient BRCA1 focal recruitment, and suppress excessive DSB (DNA double-strand breaks) end processing, homologous recombination-type DSB repair, and overt chromosomal instability |
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plays a crucial role in the DNA damage response and in maintaining genomic integrity |
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play a key role in DNA damage response (DDR) signaling by facilitating the translocation of several DDR mediators, including BRCA1, to ionizing irradiation (IR)-induced foci |
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is crucial in cell cycle checkpoint activation and DNA damage repair |
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plays a central role in the damage response by targeting BRCA1/BRCA2 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chains |
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plays a key role in the recruitment process through the binding of Lys(63)-linked poly-Ub chains by tandem Ub interacting motifs (UIM) |
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is a critical gatekeeper in impeding EMT-induced metastasis and malignant phenotypes of cancer as well as preserving DNA integrity. |
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localizes to sites of DNA insults to enhance the DNA-damage responses |
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