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FLASH GENE
Symbol SLITRK6 contributors: mct - updated : 12-05-2015
HGNC name SLIT and NTRK-like family, member 6
HGNC id 23503
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domains containing two clusters of LRRs (16 LRR (leucine-rich) repeats)
  • HOMOLOGY
    interspecies homolog to rattus LOC290467
    ortholog to murine Slitrk6
    Homologene
    FAMILY SLITRK family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • suppresses neurite outgrowth
  • promotes innervation and survival of inner ear sensory neurons by regulating the expression of trophic and/or tropic factors including neurotrophins from sensory epithelia
  • has a critical role in the development of the inner ear neural circuit
  • implicated in mediating basic neuronal processes, ranging from neurite outgrowth and dendritic elaboration to neuronal survival
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 are differentially localized to distinct synapse types and regulate the formation of the respective synapses in an isoform-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLITRK1, SLITRK2, SLITK3, SLITRK4, SLITRK5 and SLITRK6 appeared to interact with both PTPRD and PTPRS
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNMYP
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    brain tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Slitrk6-deficient mice showed pronounced reduction in the cochlear innervation