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FLASH GENE
Symbol NAALADL2 contributors: mct/npt - updated : 15-10-2020
HGNC name N-acetylated alpha-linked acidic dipeptidase-like 2
HGNC id 23219
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer monomer
HOMOLOGY
interspecies ortholog to murine Naladl2
Homologene
FAMILY
  • biotin--protein ligase family
  • glutamate carboxypeptidase II family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleoplasm
    text
  • localized at the basal cell surface where it promotes adhesion to extracellular matrix proteins
  • basic FUNCTION
  • activating biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting proteins
  • peptidase activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DUP3QD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    significantly decreased in the tissues of patients with inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) compared to those in control tissues
    tumoral     --over  
    in colon and prostate tumours when compared with benign tissue
    Susceptibility
  • to Kawasaki disease (KD)
  • to intestinal Behçet's disease
  • Variant & Polymorphism SNP
  • rs17531088 significantly associated to KS (Burgner 2009)
  • NAALADL2 gene locus (rs3914501),is associated with intestinal Behçet's disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS