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FLASH GENE
Symbol LMTK3 contributors: mct - updated : 18-11-2014
HGNC name lemur tyrosine kinase 3
HGNC id 19295
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY LMTK family of protein kinases
CATEGORY
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • tyrosine kinase activity
  • role for LMTK3 in both innate (intrinsic) and acquired (adaptive) endocrine resistance in breast cancer
  • potential role for LMTK3 in promoting integrin activity during breast cancer progression and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a regulator of the estrogen receptor-alpha (ESR1)
  • is involved in the endocytic trafficking of N-methyl-d-aspartate receptors, a type of ionotropic glutamate receptor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • LMTK3 expression was an independent poor prognostic factor in ESR1-positive breast cancer patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    new therapeutic target in breast cancer
    ANIMAL & CELL MODELS
  • Lmtk3(-/-) mice exhibit abnormal behaviors, including pronounced locomotor hyperactivity, reduced anxiety behavior, and decreased depression-like behavior