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FLASH GENE
Symbol ZKSCAN4 contributors: mlc - updated : 24-11-2007
HGNC name zinc finger with KRAB and SCAN domains
HGNC id 13854
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven C2H2-type zinc fingers
  • one KRAB domain
  • one SCAN box domain
  • an LER domain
    • HOMOLOGY
    Homologene
    FAMILY krüppel C2H2-type zinc-finger protein family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • might suppress p53-p21 pathway through activating MDM2 and EP300 expression and inducing TP53 degradation
  • transcriptional repressor that inhibits p53 and p21 transcriptional activity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS